Melting ice in Greenland may have helped to shift the location of the North Pole.
Nature News doi: 10.1038/nature.2013.12994
DNA casts doubt on Egyptian origin for ancient Cretans.
Nature News doi: 10.1038/nature.2013.12990
Initiative will use crowdsourced data to inform global carbon modelling.
Nature News doi: 10.1038/nature.2013.12969
Controlled explosions could aid monitoring of active eruptions.
Nature News doi: 10.1038/nature.2013.12970
Throughout the animal kingdom, steroid hormones have been implicated in the defense against microbial infection, but how these systemic signals control immunity is unclear. Here, we show that the steroid hormone ecdysone controls the expression of the pattern recognition receptor PGRP-LC in Drosophila, thereby tightly regulating innate immune recognition and defense against bacterial infection. We identify a group of steroid-regulated transcription factors as well as two GATA transcription factors that act as repressors and activators of the immune response and are required for the proper hormonal control of PGRP-LC expression. Together, our results demonstrate that Drosophila use complex mechanisms to modulate innate immune responses, and identify a transcriptional hierarchy that integrates steroid signalling and immunity in animals.
Bacterium helps to regulate metabolism in mice.
Nature News doi: 10.1038/nature.2013.12975
Comparison between hominins suggests modern middle-ear bones evolved early.
Nature News doi: 10.1038/nature.2013.12976
Funding goal for 2020 revised from 3% of GDP to 2%, and state share will be cut.
Nature News doi: 10.1038/nature.2013.12964
Protein relieves age-related stiffening and thickening of cardiac muscle.
Nature News doi: 10.1038/nature.2013.12971
Critics say clinical manual unfit for mental-health research.
Nature News doi: 10.1038/nature.2013.12972