Feed aggregator

B-type natriuretic peptide and C-reactive protein in the prediction of atrial fibrillation risk: the CHARGE-AF Consortium of community-based cohort studies

eScholarship@UMMS - Fri, 10/17/2014 - 12:48pm

AIMS: B-type natriuretic peptide (BNP) and C-reactive protein (CRP) predict atrial fibrillation (AF) risk. However, their risk stratification abilities in the broad community remain uncertain. We sought to improve risk stratification for AF using biomarker information.

METHODS AND RESULTS: We ascertained AF incidence in 18 556 Whites and African Americans from the Atherosclerosis Risk in Communities Study (ARIC, n=10 675), Cardiovascular Health Study (CHS, n = 5043), and Framingham Heart Study (FHS, n = 2838), followed for 5 years (prediction horizon). We added BNP (ARIC/CHS: N-terminal pro-B-type natriuretic peptide; FHS: BNP), CRP, or both to a previously reported AF risk score, and assessed model calibration and predictive ability [C-statistic, integrated discrimination improvement (IDI), and net reclassification improvement (NRI)]. We replicated models in two independent European cohorts: Age, Gene/Environment Susceptibility Reykjavik Study (AGES), n = 4467; Rotterdam Study (RS), n = 3203. B-type natriuretic peptide and CRP were significantly associated with AF incidence (n = 1186): hazard ratio per 1-SD ln-transformed biomarker 1.66 [95% confidence interval (CI), 1.56-1.76], P < 0.0001 and 1.18 (95% CI, 1.11-1.25), P < 0.0001, respectively. Model calibration was sufficient (BNP, chi(2) = 17.0; CRP, chi(2) = 10.5; BNP and CRP, chi(2) = 13.1). B-type natriuretic peptide improved the C-statistic from 0.765 to 0.790, yielded an IDI of 0.027 (95% CI, 0.022-0.032), a relative IDI of 41.5%, and a continuous NRI of 0.389 (95% CI, 0.322-0.455). The predictive ability of CRP was limited (C-statistic increment 0.003). B-type natriuretic peptide consistently improved prediction in AGES and RS.

CONCLUSION: B-type natriuretic peptide, not CRP, substantially improved AF risk prediction beyond clinical factors in an independently replicated, heterogeneous population. B-type natriuretic peptide may serve as a benchmark to evaluate novel putative AF risk biomarkers. Cardiology 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Health Information-Seeking on Behalf of Others: Characteristics of "Surrogate Seekers"

eScholarship@UMMS - Fri, 10/17/2014 - 12:48pm

Understanding the behaviors of surrogate seekers (those who seek health information for others) may guide efforts to improve health information transmission. We used 2011-2012 data from the Health Information National Trends Survey to describe behaviors of online surrogate seekers. Respondents were asked about use of the Internet for surrogate-seeking over the prior 12 months. Data were weighted to calculate population estimates. Two thirds (66.6 %) reported surrogate-seeking. Compared to those who sought health information online for only themselves, surrogate seekers were more likely to live in households with others (weighted percent 89.4 vs. 82.5 % of self-seekers; p < 0.05); no significant differences in sex, race, income or education were observed. Surrogate seekers were more likely to report activities requiring user-generated content: email communication with healthcare providers; visits to social networking sites to read and share about medical topics and participation in online health support groups. On multivariate analysis, those who had looked online for healthcare providers were more likely to be surrogate seekers (OR 1.67, 95 % CI 1.08-2.59). In addition to seeking health information, surrogate seekers create and pass along communications that may influence medical care decisions. Research is needed to identify ways to facilitate transmission of accurate health information.

Providers' perceptions of communication breakdowns in cancer care

eScholarship@UMMS - Fri, 10/17/2014 - 12:48pm

BACKGROUND: Communication breakdowns in cancer care are common and represent a failure in patient-centered care. While multiple studies have elicited patients' perspectives on these breakdowns, little is known about cancer care providers' attitudes regarding the causes and potential solutions.

OBJECTIVE: To examine providers' (1) perceptions of the nature and causes of communication breakdowns with patients in cancer care and (2) suggestions for managing and preventing breakdowns.

DESIGN: Qualitative study of nine focus groups held at three sites (Massachusetts, Georgia and Washington).

PARTICIPANTS: Fifty-nine providers: 33% primary care physicians, 14% oncologists, 36% nurses, and 17% nurse practitioners, physician assistants, and others.

APPROACH: Directed content analysis of focus group transcripts.

KEY RESULTS: Providers' perceptions of the causes of communication breakdowns fell into three categories: causes related to patients, providers, or healthcare systems. Providers perceived that patients sometimes struggle to understand cancer and health-related information, have unrealistic expectations, experience emotional and psychological distress that interferes with information exchange; and may be reticent to share their confusion or concerns. Providers described their own and colleagues' contributions to these breakdowns as sharing inaccurate, conflicting, or uncoordinated information. Providers also described the difficulty in balancing hope with reality in discussions of prognosis. System issues named by providers included insufficient time with patients, payment systems, and changing protocols that inhibit communication and coordination of care. Potential solutions included greater patient engagement, team coordination, and systems that promote patient feedback.

CONCLUSIONS: Providers described multiple causes for communication breakdowns at the patient, provider, and system level. Multi-level interventions that coordinate care and encourage feedback may help to address or prevent communication breakdowns.

Illumina backs three genomics startups

news@nature - Fri, 10/17/2014 - 12:21pm

Sequencing firm's incubator programme aims to develop its technology for wider applications.

Nature News doi: 10.1038/nature.2014.16158

CardioBuzz: Dueling Guidelines

Headlines from MedPage Today® - Fri, 10/17/2014 - 12:00pm
(MedPage Today) -- The National Lipid Association went a different way on cholesterol treatment targets. Here's why.

Stem-cell success poses immunity challenge for diabetes

news@nature - Fri, 10/17/2014 - 11:21am

Researchers must now work out how to protect cell transplants from the immune systems of people with type 1 diabetes.

Nature 514 281 doi: 10.1038/514281a

Reporting Bias: No Love for Real Low-Carb Research

Headlines from MedPage Today® - Fri, 10/17/2014 - 11:06am
(MedPage Today) -- Why are diet studies designed and interpreted so badly?

BP Control Poor in Psoriasis Patients

Headlines from MedPage Today® - Fri, 10/17/2014 - 10:30am
(MedPage Today) -- Extensive skin involvement linked with uncontrolled hypertension.

Morning Break: Ebola Fear, Pets, and Football

Headlines from MedPage Today® - Fri, 10/17/2014 - 9:45am
(MedPage Today) -- Health news and commentary from around the Web, gathered by the MedPage Today staff.

Ebola: Special Treatment Centers Needed?

Headlines from MedPage Today® - Thu, 10/16/2014 - 6:42pm
(MedPage Today) -- Dallas cases illustrate the challenges of Ebola care in a conventional setting.

Ebola Hospital: 'We Made Mistakes'

Headlines from MedPage Today® - Thu, 10/16/2014 - 6:22pm
(MedPage Today) -- Failed to make the correct diagnosis in the first place, House panel told.

Confusion Clouds U.S. Ebola Response

Headlines from MedPage Today® - Thu, 10/16/2014 - 6:00pm
(MedPage Today) -- From symptoms to treatment protocols, Ebola is a moving target.

FDA Panel: Chantix Boxed Warning Should Stay (CME/CE)

Headlines from MedPage Today® - Thu, 10/16/2014 - 4:36pm
(MedPage Today) -- Some panelists said it doesn't go far enough.

Newman's Notes: Rethink Cardio Risk Factors (CME/CE)

Headlines from MedPage Today® - Thu, 10/16/2014 - 4:00pm
(MedPage Today) -- Why it's not the "wonderful healthcare system" that saves lives from cardiovascular risks.

Giant gene banks take on disease

news@nature - Thu, 10/16/2014 - 3:21pm

Researchers bring together troves of DNA sequences in the hope of teasing out links between traits and genetic variants.

Nature 514 282 doi: 10.1038/514282a

The Promise and Peril of ACOs

Headlines from MedPage Today® - Thu, 10/16/2014 - 3:07pm
(MedPage Today) -- Doctors don't want ACOs second-guessing everything they do.

Calif.'s Prop. 46 Pits Docs Against Lawyers

Headlines from MedPage Today® - Thu, 10/16/2014 - 3:00pm
(MedPage Today) -- Bill would require a database check for painkiller prescriptions.

Quick Weight Loss Works, Too

Headlines from MedPage Today® - Thu, 10/16/2014 - 2:17pm
(MedPage Today) -- Dieters regained the same amount of weight in the long run whether they initially shed pounds fast or slow.

No RA Benefit With Remicade Addition

Headlines from MedPage Today® - Thu, 10/16/2014 - 2:00pm
(MedPage Today) -- Researchers report no difference in remission rates or radiographic changes.

Through the nanoscope: A Nobel Prize gallery

news@nature - Thu, 10/16/2014 - 1:21pm

A selection of 'super-resolution' images taken with the techniques that won the 2014 Nobel Prize for Chemistry.

Nature News doi: 10.1038/nature.2014.16129

Syndicate content