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Stroke Rounds: Post-Acute Peptide Tx Reduces Disability

Headlines from MedPage Today® - Fri, 11/20/2015 - 3:00pm
(MedPage Today) -- Functional outcomes better with novel neuropeptide treatment in early phase trial

Stroke Rounds: Bilingual Brains Sustain Less Stroke Damage (CME/CE)

Headlines from MedPage Today® - Fri, 11/20/2015 - 2:30pm
(MedPage Today) -- Speaking another language protective in observational study

Perceiving one's heart condition to be cured following hospitalization for acute coronary syndromes: Implications for patient-provider communication

eScholarship@UMMS - Fri, 11/20/2015 - 2:26pm

OBJECTIVE: We examined the proportion of patients perceiving their heart condition to be cured following hospitalization for ACS and identified characteristics associated with these perceptions.

METHODS: We conducted a prospective cohort study of adults hospitalized with ACS (N=396). Patient interviews during hospitalization and one week post-discharge provided demographic and psychosocial characteristics. Medical records provided clinical characteristics. At one week, patients who rated "My heart condition is cured" as "definitely true" or "mostly true" were considered to perceive their heart condition cured.

RESULTS: Participants were aged 60.7 (SD:11.0) years, 26.5% female, and 89.0% non-Hispanic white; 16.7% had unstable angina, 59.6% NSTEMI, and 23.7% STEMI. One week post-discharge, 30.3% perceived their heart condition to be cured. Characteristics associated with cure perceptions were older age (OR=2.2; 95% CI: 1.2-4.0 for > /=65 years vs < 55 years), male sex (OR=2.4; 95%CI: 1.3-4.2), history of hypertension (OR=1.8; 95%CI: 1.1-3.1), history of stroke (OR=4.2; 95%CI: 1.1-16.7), no history of CHD (OR=2.8; 95%CI: 1.6-4.9), and receipt of CABG during hospitalization (OR=4.8, 95%CI: 1.9-12.0 vs medical management).

CONCLUSION: One week post-discharge, 3 in 10 patients perceived their heart condition to be cured.

PRACTICE IMPLICATIONS: Conversations with patients should frame ACS as a chronic disease and dispel cure perceptions.

A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection

eScholarship@UMMS - Fri, 11/20/2015 - 2:26pm

Virus-specific CD8(+) T cells expand dramatically during acute EBV infection, and their persistence is important for lifelong control of EBV-related disease. To better define the generation and maintenance of these effective CD8(+) T cell responses, we used microarrays to characterize gene expression in total and EBV-specific CD8(+) T cells isolated from the peripheral blood of 10 individuals followed from acute infectious mononucleosis (AIM) into convalescence (CONV). In total CD8(+) T cells, differential expression of genes in AIM and CONV was most pronounced among those encoding proteins important in T cell activation/differentiation, cell division/metabolism, chemokines/cytokines and receptors, signaling and transcription factors (TF), immune effector functions, and negative regulators. Within these categories, we identified 28 genes that correlated with CD8(+) T cell expansion in response to an acute EBV infection. In EBV-specific CD8(+) T cells, we identified 33 genes that were differentially expressed in AIM and CONV. Two important TF, T-bet and eomesodermin, were upregulated and maintained at similar levels in both AIM and CONV; in contrast, protein expression declined from AIM to CONV. Expression of these TF varied among cells with different epitope specificities. Collectively, gene and protein expression patterns suggest that a large proportion, if not a majority of CD8(+) T cells in AIM are virus specific, activated, dividing, and primed to exert effector activities. High expression of T-bet and eomesodermin may help to maintain effector mechanisms in activated cells and to enable proliferation and transition to earlier differentiation states in CONV.

FDA Approves Oral Ixazomib for Myeloma

Headlines from MedPage Today® - Fri, 11/20/2015 - 2:22pm
(MedPage Today) -- Proteasome inhibitor is third myeloma approval for 2015

Cultural differences determine when kids learn to play fair

news@nature - Fri, 11/20/2015 - 2:21pm

Children in many — but not all ― societies reject unfair deals by the age of eight.

Nature News doi: 10.1038/nature.2015.18816

Navigating to Better Care

Headlines from MedPage Today® - Fri, 11/20/2015 - 2:00pm
(MedPage Today) -- Does every patient need a "navigator"? Maybe so

Sleep Matters for Obesity

Headlines from MedPage Today® - Fri, 11/20/2015 - 1:30pm
(MedPage Today) -- A focus on sleep hygiene can help patients with overall health, too

NIH to retire all research chimpanzees

news@nature - Fri, 11/20/2015 - 1:21pm

Fifty animals held in “reserve” by the US government will be sent to sanctuaries.

Nature News doi: 10.1038/nature.2015.18817

Comprehensive Tx Gives Best Results in RA (CME/CE)

Headlines from MedPage Today® - Fri, 11/20/2015 - 1:01pm
(MedPage Today) -- Patient-centered outcomes improve most when control achieved in all disease domains

Artificial Pancreas Effective for Patients With Pancreatitis, T1D (CME/CE)

Headlines from MedPage Today® - Fri, 11/20/2015 - 12:30pm
(MedPage Today) -- 72-hour trial tests the devices on islet transplantation patients

Orencia Safe in RA, Even With HBV (CME/CE)

Headlines from MedPage Today® - Fri, 11/20/2015 - 12:00pm
(MedPage Today) -- An Italian study found no cases of viral reactivation over 2 years

Light Therapy May Be Effective Year Round for Major Depression

Headlines from MedPage Today® - Fri, 11/20/2015 - 11:30am
(MedPage Today) -- Improvements seen when used alone or with an SSRI antidepressant

China's bold push into genetically customized animals

news@nature - Fri, 11/20/2015 - 11:21am

New kinds of dogs, goats, monkeys and pigs are being made quickly, though scientists voice worries about ethics.

Nature News doi: 10.1038/nature.2015.18826

Slow Medicine: Time to Let Go of 140/90?

Headlines from MedPage Today® - Fri, 11/20/2015 - 11:00am
(MedPage Today) -- The Slow Medicine approach to the SPRINT trial results

Amgen Pledges to Respect Patient Privacy

Headlines from MedPage Today® - Fri, 11/20/2015 - 10:30am
(MedPage Today) -- Backs off data rights demand for patients seeking co-pay help

Could Old Gout Drug Offer New CV Benefits? (CME/CE)

Headlines from MedPage Today® - Fri, 11/20/2015 - 10:00am
(MedPage Today) -- Colchicine use was associated with fewer cardiovascular events and lower all-cause mortality

Tenofovir Prevents HBV Transmission in Pregnancy

Headlines from MedPage Today® - Fri, 11/20/2015 - 9:30am
(MedPage Today) -- Safe and well tolerated when started weeks 30 to 32 gestation

Modeling Epidemics Spreading on Social Contact Networks

eScholarship@UMMS - Fri, 11/20/2015 - 9:09am

Social contact networks and the way people interact with each other are the key factors that impact on epidemics spreading. However, it is challenging to model the behavior of epidemics based on social contact networks due to their high dynamics. Traditional models such as susceptible-infected-recovered (SIR) model ignore the crowding or protection effect and thus has some unrealistic assumption. In this paper, we consider the crowding or protection effect and develop a novel model called improved SIR model. Then, we use both deterministic and stochastic models to characterize the dynamics of epidemics on social contact networks. The results from both simulations and real data set conclude that the epidemics are more likely to outbreak on social contact networks with higher average degree. We also present some potential immunization strategies, such as random set immunization, dominating set immunization, and high degree set immunization to further prove the conclusion.

Morning Break: Sniffing Out Cancer; Frankenfish OK'd; Ebola and STD Comebacks

Headlines from MedPage Today® - Fri, 11/20/2015 - 8:45am
(MedPage Today) -- Health news and commentary from around the Web, gathered by the MedPage Today staff
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