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Team Teaching, Humor, and Informal Polling Techniques in NECDMC - Based Research Data Management Workshops at Brandeis University

Wed, 04/06/2016 - 3:30pm

Objective: This poster will detail a few pedagogical techniques incorporated into a series of workshops on research data management. These techniques were chosen to better engage workshop participants by making the material more individually relevant and relatable.

Methods: For the second semester in which workshops on research data management (derived from the NECDMC modules) were offered through the Brandeis University Library & Technology Services department, the librarian sought to make the sessions more engaging through several pedagogical techniques. A team teaching approach was employed by inviting senior members of the Technology Help Desk and Hardware Repair Shop to collaborate on and co-teach the workshops. Humor was employed strategically through icons, disaster stories, and select xkcd webcomic strips within the lecture and slides. Informal polling and direct encouragement to share personal anecdotes during the workshop sessions promoted active engagement.

Results: Workshop participants were visibly more engaged, asked a greater number of questions, and questions were more directly relevant to the presented material than participants of the first semester's workshops, before these pedagogical techniques were employed.

Conclusions: Active and engaged learning techniques are difficult to employ in what are essentially one-shot hour-long instruction sessions, particularly when participants are largely unfamiliar with the material at hand. But by integrating some techniques to capture the interest and encourage participants to make connections to their own experiences we observed a deeper understanding and appreciation of the material.

BU’s Study Group: Partners in Learning

Wed, 04/06/2016 - 3:30pm

Objective: Building awareness of new library services on any campus can be difficult, especially when these services are deemed “non-traditional.” To help us overcome this challenge, the Boston University Libraries’ partnered with the Mozilla Science Lab to launch a new initiative called “Study Group” on campus. This poster describes Mozilla’s community building philosophy, the initial results of this partnership, and the technologies we have used.

Methods: The Mozilla Science Lab launched its Study Group initiative during the spring of 2015 to help researchers practice open science through community-led, technology-driven workshops. Group members lead each workshop in an informal, approachable way that encourages members to be both teachers and learners. This approach has created a venue for librarians to engage with graduate students as peers and has opened new two-way communication channels. Additionally, by using open technologies advocated by Mozilla, like GitHub and Gitter, the library now engages researchers on the platforms they already prefer.

Results: Our first two events this spring had ten and twelve participants respectively and we have another ten events scheduled. Last fall we held six events with a total of fifty-five participants. This spring we have held nine events with a total of forty-four participants. Of note, library staff have led only two sessions. This is an important achievement because it has limited our investment in staff time while still allowing us to achieve beneficial outreach results. Less tangibly, participants are beginning to view the library as a partner in open research, as a resource for data sharing, and as a more technology-driven organization. Finally, outside of staff time our total investment (including launching has been $240 – predominantly for posters and other outreach materials.

Conclusions: Partnering with the Mozilla Science Lab has helped the library engage with graduate researchers in the sciences through community building in a peer-to-peer format. This relationship has helped both the BU Libraries and Mozilla achieve their respective goals to engage researchers in open research practices in a mutually beneficial way.

Serving an Information Potluck at the Research Data Management Roundtable

Wed, 04/06/2016 - 3:30pm

Objectives: The Research Data Management Roundtables are a collaborative effort to address the shared challenges relating to data services and the role of the library. Outside of listservs, conferences, or other multi-day events, there are few means to discuss issues related to beginning or sustaining data management initiatives among organizations, libraries, and librarians. The Roundtables are one method to address this issue.

Methods: The New England eScience Program (NN/LM NER) sponsored two Roundtable discussions in 2015. Each was a one day event, and included an activity based in the local area and the Roundtable discussion. Around twenty librarians from multiple New England institutions met at central locations in Amherst and Worcester, Massachusetts. The committee members facilitated the discussions with guidelines and pre-determined topics.

Results: “Outcomes” from the two discussions were posted to the e-Science Portal for New England Librarians Community Blog. The first Roundtable focused on “organizational structures for research data management services at our institutions,” and the second discussed “engaging faculty and graduate student researchers at our institutions.” Feedback on the most useful aspects of the Roundtables included: “questions were very helpful to guide the discussion”; “hearing other librarians’ ideas and successes, and commiserating about weaknesses and challenges”; and “learning I’m not the only one with questions.”

Conclusions: The Roundtables have been successful professional development for librarians to share experiences and training with other librarians, in order to broaden their knowledge about RDS. Suggestions for the future include discussions on: data policies, policy development, and examples; how to gain traction with administration; and collaborating across campus.

Bridging the Gap: Improving Data Services through Cross-Campus Collaboration

Wed, 04/06/2016 - 3:30pm

Objective: New York University (NYU) Libraries provide research data services to diverse communities across several campuses. Until recently, they have worked mostly independent of each other. At the main campus, NYU Data Services offers workshops, individual and group consultations, and traveling “road shows” on data management to the larger NYU community. At a separate medical center campus, the NYU Health Sciences Library (NYUHSL) supports a data catalog, data management education, and individualized lab support. Finally, Databrary, which is connected to NYU’s Digital Library Technology Services, provides a repository for behavioral and learning science researchers working primarily with video data to store, manage, and share the raw materials of their work with their colleagues. This poster will discuss how these disparate services have worked more closely together by identifying overlap, making connections between service offerings, and sharing knowledge and resources around data. This initiative better enriches the overall mission and strategy of NYU libraries to serve its student and research communities.

Methods: To ensure the better coordination of these data services, we began to hold regular, bi-monthly meetings to discuss strategies for improving data education material, integrating an institutional data catalog created by NYUHSL with main campus systems, and providing data-related outreach to institutional stakeholders. These groups have also collaborated on planning and hosting events on data-related topics including using Databrary, reproducibility in science, and data visualization. Finally, a resource sharing system was instituted across campuses for library faculty to collaborate and improve upon the instructional design of data management education, create outreach materials, and share ongoing project documentation.

Results: The new collaboration between NYU Data Services, NYUHSL and special projects like Databrary has served to break down existing institutional silos to provide better research and educational data services to NYU’s student and research communities. This collaboration has been essential for improving upon existing services, identifying new opportunities to support the data needs of institutional stakeholders, and providing increased levels of outreach. By fostering a better understanding of what data services are available across campuses through this ongoing collaboration, we are better able to identify and support our communities’ data needs.

Conclusion: Providing data management, curation, and storage services for a diverse and dynamic research community on campus is a demanding task that requires a distributed effort. Each service fills different gaps for researchers at varying stages of their research practices, though without inter-department communication there was decidedly less impact and reach by everyone. By collaborating and opening a line of communication, we have built a better understanding of how we can interact to provide stronger support to the student and research communities across campuses.

Helping a Department of Energy Laboratory respond to Public Access requirements

Wed, 04/06/2016 - 3:30pm

Objective: The Princeton Plasma Physics Laboratory (PPPL) is a Department of Energy (DOE) Laboratory operated by Princeton University. The DOE released a Public Access plan in October of 2014 in response to the White House Office of Science and Technology Policy (OSTP) memo from February of 2013 titled “Increasing Access to the Results of Federally Funded Scientific Research”. To determine how the Princeton University Library and Office of Information Technology can help PPPL comply with the DOE Public Access Plan.

Methods: Several meetings were held between the PPPL committee charged with Public Access Plan compliance, the E-science and Scholarly Communications Librarians, and Princeton’s Dspace repository architect and programmer. These meetings served to help librarians provide PPPL with information about OSTP and DOE requirements and to determine how the Library and OIT could help PPPL with compliance.

Results: Librarians helped align the PPPL Data Management Plan with DOE requirements. Librarians also helped PPPL’s communications and technology licensing understanding of Open Access to published research and consult on publisher copyright policies. The E-Science Librarian, DSpace repository architect, and DSpace programmer worked with PPPL to set up a DSpace community, associated metadata, and guidelines for documentation to make the data underlying publications publicly accessible.

Conclusion: Many U. S. funding agencies have released the Public Access plans in response the OSTP Memo from February 2013 with requirements for open access to articles, data management plans, and making data underlying publications publicly available. Librarians can play a role in helping their institutions respond to these requirements.

Compliance: Data Management Plans and Public Access to Data

Wed, 04/06/2016 - 1:30pm

Three years ago, the Office of Science and Technology Policy released the memo “Increasing Public Access to the Results of Federally Funded Research.” So far, 16 agencies have released plans. These new requirements relate to information access so librarians are well placed to help researchers and grants administrators comply. Many librarians have previous experience with NIH Public Access Policy and/or NSF data management plan requirements, so the transition to the new mandates should be easy. This breakout session will help you focus your efforts on the most important aspects of public access and data management plans when helping researchers with compliance.

Margaret Henderson is Director of Research Data Services and Hillary Miller is Scholarly Communications Outreach Librarian, Virginia Commonwealth University Libraries.

Informationist: Informationist Breakout Session

Wed, 04/06/2016 - 1:30pm

In this session Leah will discuss her experiences working on an NIH Supplement for Informationist Services grant, what was accomplished, and what she learned along the way. Within the psychiatric neuroimaging research community, data and resource sharing have become accepted as standard, but issues related to attribution and citing data in novel research are still hindering meaningful reuse. This project aimed to illustrate a system of data identification that would not only allow for proper citation of whole datasets, but maintain the chain of attribution in derived and remixed datasets, allowing for a more complete picture of research impact and author contribution.

Leah Honor is Library Fellow and Informationist Liaison to the Child and Adolescent Neurodevelopment Initiative, University of Massachusetts Medical School.

Data Information Literacy: Developing Data Information Literacy Programs

Wed, 04/06/2016 - 1:30pm

Researchers are under increasing pressure to manage, organize, describe and document their data in ways that enable others to discover, understand and reuse their work. However, the knowledge and skills needed to be successful in these tasks are not often a part of a student's education in college or graduate school. Librarians have an opportunity to address this gap in student's education through developing data literacy programming, but developing effective data literacy programs can seem daunting.

This session will introduce students to a model for creating data literacy programming developed as a part of the Data Information Literacy project. We will begin by reviewing the findings from interviews conducted with faculty and students at four universities. We will then walk through the DIL model step by step. Finally, participants will work through case studies to explore potential opportunities and generate possible approaches to offering data literacy programs.

Jake Carlson is Research Data Services Manager, University of Michigan.

Data Repositories: The Answer that Actually Came with a Question

Wed, 04/06/2016 - 1:30pm

Data repositories: the answer that actually came with a question. Funders, journal publishers, and disciplinary societies recognize the benefits of long-term access to valuable data that could validate results, increase scholarly democracy, or possibly lead to future discoveries. With this in mind, a majority of research now being done in academia is subject to data sharing requirements that the underlying data be publicly accessible, citable, and persevered. As many subject-based data repositories help make this happen, particularly for computing-intensive disciplines with shared infrastructure, such as high-energy physics or real-time climate monitoring, who will manage the "long-tail" of smaller or multi-disciplinary research data?

Our institutional repositories (IR) could be the answer. With a few key policy decisions, and robust review and curation procedures, libraries are well-positioned to help researchers comply with mandates to share and archive their data. Whether you use Hydra, DSpace, Fedora, E-prints, or Digital Commons, this talk will outline important issues to consider as you build new capacity with existing IR infrastructure or a custom data repository, including staffing, curation procedures, and metadata and documentation requirements. Finally it will explore the results and faculty response to launching the Data Repository for the University of Minnesota in 2015, which is based on the Libraries’ existing IR service. Our data submission process, curation procedures, faculty usage, and lessons learned will be placed in context of our broader data management and curation program.

Lisa Johnston is Research Data Management/Curation Lead and Co-Director of the University Digital Conservancy, University of Minnesota.

Breakout Session Descriptions: 2016 University of Massachusetts and New England Area Librarian e-Science Symposium

Wed, 04/06/2016 - 1:00pm

Descriptions of the Breakout Sessions held at the 8th annual University of Massachusetts and New England Area Librarian e-Science Symposium, held Wednesday, April 6, 2016 at the University of Massachusetts Medical School, Worcester, MA. Sessions include Data Information Literacy, Compliance, Data Repositories, and Informationist.

Keynote Presentation: Data Work: Research Data Services in Canada & the U.S.

Wed, 04/06/2016 - 12:15pm

Kendall Roark, PhD, is Assistant Professor and Research Data Specialist at Purdue University. In her keynote presentation, she provides a broad perspective on the research data management services that U.S. and Canadian libraries are implementing.

Event Brochure: 2016 University of Massachusetts and New England Area Librarian e-Science Symposium

Wed, 04/06/2016 - 11:30am

Event brochure for the 8th annual University of Massachusetts and New England Area Librarian e-Science Symposium, held Wednesday, April 6, 2016, at the University of Massachusetts Medical School, Worcester, MA. The brochure includes the symposium event schedule, speaker biographies, and additional resources.

Symposium Agenda: 2016 University of Massachusetts and New England Area Librarian e-Science Symposium

Wed, 04/06/2016 - 11:30am

Agenda for the 8th annual University of Massachusetts and New England Area Librarian e-Science Symposium, held Wednesday, April 6, 2016 at the University of Massachusetts Medical School, Worcester, MA.

Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut

Fri, 04/01/2016 - 2:22pm

Given mounting evidence of the importance of gut-microbiota/immune-cell interactions in immune homeostasis and responsiveness, surprisingly little is known about leukocyte movements to, and especially from, the gut. We address this topic in a minimally perturbant manner using Kaede transgenic mice, which universally express a photoconvertible fluorescent reporter. Transcutaneous exposure of the cervical lymph nodes to violet light permitted punctual tagging of immune cells specifically therein, and subsequent monitoring of their immigration to the intestine; endoscopic flashing of the descending colon allowed specific labeling of intestinal leukocytes and tracking of their emigration. Our data reveal an unexpectedly broad movement of leukocyte subsets to and from the gut at steady state, encompassing all lymphoid and myeloid populations examined. Nonetheless, different subsets showed different trafficking proclivities (e.g., regulatory T cells were more restrained than conventional T cells in their exodus from the cervical lymph nodes). The novel endoscopic approach enabled us to evidence gut-derived Th17 cells in the spleens of K/BxN mice at the onset of their genetically determined arthritis, thereby furnishing a critical mechanistic link between the intestinal microbiota, namely segmented filamentous bacteria, and an extraintestinal autoinflammatory disease.

Chronic kidney disease prevalence in Rivas, Nicaragua: use of a field device for creatinine measurement

Fri, 04/01/2016 - 2:20pm

OBJECTIVE: An epidemic of chronic kidney disease (CKD) has been identified in Pacific coastal regions of Central America, and screening in the field in these low income countries remains logistically problematic. We tested the performance characteristics of a point of care creatinine analyzer compared to standardized serum creatinine measurements.

METHODS: Measurements were conducted in 100 persons from a local health center (n=34) and hospital (n=66) in Rivas, Nicaragua using both a point-of-care analyzer (StatSensor Xpress, Nova Biomedical) and serum creatinine by Jaffe kinetic method with a Roche Cobas Integra 400 analyzer. Percent coefficient of variation, sensitivity and specificity of the StatSensor Xpress were determined.

RESULTS: The average coefficient of variation (CV) was 1.28% for the serum creatinine and CV for the StatSensor Xpress analyzer was 6.8%. The median intra-individual creatinine results obtained with the StatSensor Xpress device were 0.32 mg/dL higher than those by serum creatinine by Jaffe kinetic method. The sensitivity and specificity of the StatSensor Xpress device for identifying subjects with abnormal creatinine (defined as > 1.2 mg/dL) was 100% and 79%, respectively.

CONCLUSIONS: Point of care testing for creatinine demonstrated acceptable repeatability, excellent sensitivity (100%) and modest specificity (79%). Using the point of care testing will allow for generalized screening in the field in low income countries; however, confirmation for elevated levels > 1.2 mg/dL will require a second laboratory test confirmation.

Adjuvant chemotherapy for invasive bladder cancer: a 2013 updated systematic review and meta-analysis of randomized trials

Fri, 04/01/2016 - 2:20pm

CONTEXT: The role of adjuvant chemotherapy remains poorly defined for the management of muscle-invasive bladder cancer (MIBC). The last meta-analysis evaluating adjuvant chemotherapy, conducted in 2005, had limited power to fully support its use.

OBJECTIVE: To update the current evidence of the benefit of postoperative adjuvant cisplatin-based chemotherapy compared with control (ie, surgery alone) in patients with MIBC.

EVIDENCE ACQUISITION: A comprehensive literature review was performed to identify all randomized controlled trials (RCTs) comparing adjuvant cisplatin-based chemotherapy with control for patients with MIBC. The search included the Medline, Embase, Cochrane Central Register of Controlled Trials databases, and abstracts from the American Society of Clinical Oncology meetings up to May 2013. An updated systematic review and meta-analysis was performed.

EVIDENCE SYNTHESIS: A total of 945 patients included in nine RCTs (five previously analyzed, one updated, and three new) were examined. For overall survival, the pooled hazard ratio (HR) across all nine trials was 0.77 (95% confidence interval [CI], 0.59-0.99; p=0.049). For disease-free survival, the pooled HR across seven trials reporting this outcome was 0.66 (95% CI, 0.45-0.91; p=0.014). This disease-free survival benefit was more apparent among those with positive nodal involvement (p=0.010).

CONCLUSIONS: This updated and improved meta-analysis of randomized trials provides further evidence of an overall survival and disease-free survival benefit in patients with MIBC receiving adjuvant cisplatin-based chemotherapy after radical cystectomy.

A systematic review and meta-analysis of adjuvant and neoadjuvant chemotherapy for upper tract urothelial carcinoma

Fri, 04/01/2016 - 2:20pm

CONTEXT: The role of adjuvant chemotherapy (AC) or neoadjuvant chemotherapy (NC) remains poorly defined for the management of upper tract urothelial carcinoma (UTUC), although some studies suggest a benefit.

OBJECTIVE: To update the current evidence on the role of NC and AC for UTUC patients.

EVIDENCE ACQUISITION: We searched for all studies investigating NC or AC for UTUC in Medline, Embase, the Cochrane Central Register of Controlled Trials, and abstracts from the American Society of Clinical Oncology meetings prior to February 2014. A systematic review and meta-analysis were performed.

EVIDENCE SYNTHESIS: No randomized trials investigated the role of AC for UTUC. There was one prospective study (n=36) investigating adjuvant carboplatin-paclitaxel and nine retrospective studies, with a total of 482 patients receiving cisplatin-based or non-cisplatin-based AC after nephroureterectomy (NU) and 1300 patients receiving NU alone. Across three cisplatin-based studies, the pooled hazard ratio (HR) for overall survival (OS) was 0.43 (95% confidence interval [CI], 0.21-0.89; p=0.023) compared with those who received surgery alone. For disease-free survival (DFS), the pooled HR across two studies was 0.49 (95% CI, 0.24-0.99; p=0.048). Benefit was not seen for non-cisplatin-based regimens. For NC, two phase 2 trials demonstrated favorable pathologic downstaging rates, with 3-yr OS and disease-specific survival (DSS) < /= 93%. Across two retrospective studies investigating NC, there was a DSS benefit, with a pooled HR of 0.41 (95% CI, 0.22-0.76; p=0.005).

CONCLUSIONS: There appears to be an OS and DFS benefit for cisplatin-based AC in UTUC. This evidence is limited by the retrospective nature of studies and their relatively small sample size. NC appears to be promising, but more trials are needed to confirm its utility.

PATIENT SUMMARY: After a comprehensive search of studies examining the role of chemotherapy for upper tract urothelial cancer, the pooled evidence shows that cisplatin-based adjuvant chemotherapy was beneficial for prolonging survival.

Unveiling the surgical risk associated with neoadjuvant chemotherapy in bladder cancer

Fri, 04/01/2016 - 2:20pm

William Martin-Doyle participated in this study as a medical student as part of the Senior Scholars research program at the University of Massachusetts Medical School.

Reexamining treatment of high-grade T1 bladder cancer according to depth of lamina propria invasion: a prospective trial of 200 patients

Fri, 04/01/2016 - 2:19pm

BACKGROUND: Management of high-grade T1 (HGT1) bladder cancer represents a major challenge. We studied a treatment strategy according to substaging by depth of lamina propria invasion.

METHODS: In this prospective observational cohort study, patients received initial transurethral resection (TUR), mitomycin-C, and BCG. Subjects with shallower lamina propria invasion (HGT1a) were followed without further surgery, whereas subjects with HGT1b received a second TUR. Association of clinical and histological features with outcomes (primary: progression; secondary: recurrence and cancer-specific survival) was assessed using Cox regression.

RESULTS: Median age was 71 years; 89.5% were males, with 89 (44.5%) cases T1a and 111 (55.5%) T1b. At median follow-up of 71 months, disease progression was observed in 31 (15.5%) and in univariate analysis, substaging, carcinoma in situ, tumour size, and tumour pattern predicted progression. On multivariate analysis only substaging, associated carcinoma in situ, and tumour size remained significant for progression.

CONCLUSIONS: In HGT1 bladder cancer, the strategy of performing a second TUR only in T1b cases results in a global low progression rate of 15.5%. Tumours deeply invading the lamina propria (HGT1b) showed a three-fold increase in risk of progression. Substaging should be routinely evaluated, with HGT1b cases being thoroughly evaluated for cystectomy. Inclusion in the TNM system should also be carefully considered.

Factors influencing the development of antibiotic associated diarrhea in ED patients discharged home: risk of administering IV antibiotics

Fri, 04/01/2016 - 2:19pm

OBJECTIVE: Antibiotic-associated diarrhea (AAD) and Clostridium difficile infection (CDI) are well-known outcomes from antibiotic administration. Because emergency department (ED) visits frequently result in antibiotic use, we evaluated the frequency of AAD/CDI in adults treated and discharged home with new prescriptions for antibiotics to identify risk factors for acquiring AAD/CDI.

METHODS: This prospective multicenter cohort study enrolled adult patients who received antibiotics in the ED and were discharged with a new prescription for antibiotics. Antibiotic-associated diarrhea was defined as 3 or more loose stools for 2 days or more within 30 days of starting the antibiotic. C difficile infection was defined by the detection of toxin A or B within this same period. We used multivariate logistic regression to assess predictors of developing AAD.

RESULTS: We enrolled and followed 247 patients; 45 (18%) developed AAD, and 2 (1%) developed CDI. Patients who received intravenous (IV) antibiotics in the ED were more likely to develop AAD/CDI than patients who did not: 25.7% (95% confidence interval [CI], 17.4-34.0) vs 12.3% (95% CI, 6.8-17.9). Intravenous antibiotics had adjusted odds ratio of 2.73 (95% CI, 1.38-5.43), and Hispanic ethnicity had adjusted odds ratio of 3.04 (95% CI, 1.40-6.58). Both patients with CDI had received IV doses of broad-spectrum antibiotics.

CONCLUSION: Intravenous antibiotic therapy administered to ED patients before discharge was associated with higher rates of AAD and with 2 cases of CDI. Care should be taken when deciding to use broad-spectrum IV antibiotics to treat ED patients before discharge home.