Defining the Clinical Question

A 35-year old woman complains of a three day history of cough productive of moderate amounts of greenish sputum. Her illness started six days ago with a sore throat that was followed by nasal congestion, a brief episode of hoarseness, and then the cough she currently has. The nasal congestion, sore throat, and hoarseness have all resolved but the cough seems to be getting worse. She feels a mild tightness substernally and has occasional wheezes, but she denies any shortness of breath, fever, or pleuritic chest pain. She has no history of asthma and has never smoked cigarettes. On physical exam you find only a few scattered rhonchi bilaterally. Otherwise the physical exam is entirely normal. You make a diagnosis of acute bronchitis and the patient says she has usually been prescribed an antibiotic for this type of problem in the past.

Although you have prescribed antibiotics for similar patients in the past, you have recently heard that antibiotics may not be indicated in all cases of bronchitis. You wish to find out whether an antibiotic would be appropriate for this patient.

Read the case above and formulate an appropriate specific clinical question. Help on Developing a Well-Built Clinical Question

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Developing a Well-Built Clinical Question

A well-built clinical question:
  1. Describes the key features of the patient (and their disease if indicated) which could be relevant to health risks, prognosis, or choice of therapy:

    • Age range
    • Gender
    • Disease characteristics
    • Risk factors

    You will use these features to compare your patient to study populations to determine if the research results can be generalized to your patient.

  2. Describes the specific therapy (intervention) that interests you (e.g. an antibiotic)


  3. Compares an alternative treatment approach to the one you are interested in assessing


  4. Describes the specific health outcome(s) that the therapy of interest is supposed to influence:

    • Mortality rate
    • Number of days lost from work

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